For many, a COVID-19 diagnosis can still have a significant impact on their daily lives and well-being. While current COVID-19 treatments are effective, some are only available in a hospital setting, and they may not be an option for people with chronic medical conditions that are taking certain medications. It's important that all high-risk people with COVID-19 have treatment options that work for them.
About the Clinical Trial
We're conducting a clinical trial for high-risk adults and adolescents with COVID-19 who have limited treatment options or are unable to take current treatments. This clinical trial will determine if a potential antiviral treatment can safely and effectively help them recover without interacting with their current medications or causing unwanted side effects.
By choosing to participate, you will receive care from a team of dedicated healthcare professionals while helping to advance what could be a breakthrough treatment for people around the world. So, thank you for taking the time to learn more.
Who Can Participate?
This clinical trial may be an option if you:
- Are an adult 18+ or an adolescent 12+
- Have COVID-19 and developed signs or symptoms within the last 5 days
- Have certain risk factors for severe illness or complications from COVID-19 and may not be able to take currently approved treatments. Risk factors include:
- 65 years of age or older
- Obesity (Body Mass Index (BMI) over 30)
- Current smoker
- Chronic lung disease
- Asthma requiring daily prescribed therapy
- Cardiovascular disease
- Type 1 or Type 2 diabetes mellitus
- Renal impairment (kidney disease)
- Sickle cell disease
- Have a condition or take a medication that weakens your immune system
- Have not received a COVID-19 vaccine in the last 4 months
Participants will need to meet a few other criteria to take part in this clinical trial. The study team will discuss these with you in person.
Participation Matters
Ensuring diversity within clinical trials enables us to see how potential treatments work in different types of people. We’ll be looking at factors like age, sex and ethnicity to see if the treatment is effective for all people with COVID-19. Everyone needs to be represented.
What to Expect
If this clinical trial is a good fit for you and you agree to take part, you will be enrolled for around 24 weeks, and you will have about 12 appointments in total (some appointments may be by telephone).
You will have a 1 in 2 chance (50%) of receiving the study medicine or placebo. The placebo looks just like the study medicine but does not contain any active ingredients.
You will take the study medicine or placebo orally (pill) twice a day for 5 days (10 doses total).
Whether you receive the study medicine or placebo, you may still take a standard of care medicine for COVID-19 while in the clinical trial. This means you will be cared for using the current best practices determined by your study doctor.
The study treatment and study-related procedures will be provided at no cost. You will also be compensated for completing study-related activities.
Find a Study Site
If you have developed signs or symptoms of COVID-19 within the last 5 days, have tested positive, or are unsure if you have COVID-19, please contact a study team member as soon as possible. They will be able to determine if this clinical trial is a good fit for you and answer any questions you may have.
Jongaie Research
WF Nkomo Street 551 Tshwane Metro. Municipality
Pretoria, Gauteng 0183 ZA
27836502970
Langeberg Clinical Trials
Corner Brighton and Kipling Streets, Brighton Square
Kraaifontein, Western Cape 7570 ZA
27219805143
Global Clinical Trials
Corner of R55 and Lochner Road, Raslouw
Pretoria, Gauteng 0157 ZA
270123235926
DR P J SEBASTIAN CLINICAL RESEARCH CENTRE
76 Silverglen Drive, Silverglen
Durban, KwaZulu-Natal 4092 ZA
27314032252
TREAD Research
Francie Van Zijl Drive, Parow
Cape Town, Western Cape 7500 ZA
27219333597
Sandton Medical Research Centre
49 East Road, Morningside
Johannesburg, Gauteng 2196 ZA
27847862116
Synapta Clinical Research
94 Charlotte Maxeke Street
Durban, KwaZulu-Natal 4001 ZA
0313098622
Newtown Clinical Research
104 Rahima Moosa Street
Johannesburg, Gauteng 2113 ZA
27114920336
Paarl Research Centre
22 Verster Street, Lemoenkloof
Paarl, Western Cape 7646 ZA
0218724316